After Bianque became famous, he toured all the kingdoms to cure more diseases and relieve more people from suffering. His areas of treatment often changed due to different regions. In Handan, he heard that most patients were women, so he worked as a "Daixia Doctor" (doctor specializing in gynecology); when he passed by Luoyang, he saw that elders were highly revered there so he became a doctor mainly treating diseases of the old such as the trouble in the ear or the eye; when he reached Xianyang, he became a pediatrician for people of the Qin Kingdom regarded children as the most important. In his practice of diagnosis, he had already applied the comprehensive diagnostic techniques of traditional Chinese medicines, namely, the four diagnostic methods: observation, auscultation and olfaction, interrogation, and pulse-feeling and palpation. At that time, Bianque called those techniques "Wangse (observing the color of the patient), Tingsheng (listening to the voice), Xieying (drawing a primary conclusion of the symptoms) and Qiemai (feeling the pulse)". Bianque's ways of treatment varied, such as acupuncture, adhibition of medicine, operation, medicine taking and so on.

Bianque had nine disciples in his life who contributed to hand down his high medical skills from generation to generation. Till the Han Dynasty (206BC-220AD), his well-preserved works included nine volumes of Internal Canon of Medicine, twelve volumes of External Canon of Medicine, and thirteen volumes of Bianque's Prescriptions Approved by First Yellow Emperor, etc. The extant medical book of the Han Dynasty, Canon of Medicine of Difficult Diseases , is a work compiled on the basis of Bianque's medical skill, especially his knowledge on pulse-taking. Bianque was memorized and respected by Chinese people forever. Many basic theories of the traditional Chinese medicine, which is still playing a great role in the health service of mankind, are closely originated from or related to Bianque.

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