When it comes to antitumor drugs, both the physicians who prescribe them and the patients who receive them would agree that better chemotherapeutic agents are needed. Drugs in common use were designed to take advantage of general characteristics of tumor cells such as hormone responsiveness or high rates of cell division. Unfortunately, these properties are also found in some healthy cells. This general lack of specificity has led to the use of drug doses that straddle a knife edge between efficacy and toxicity. Two recent studies, one by Bryant et al.1 and the other by Farmer et al.,2 suggest that it is possible to achieve specificity without toxicity by adopting a new approach to targeting tumor cells. Login to read fulltext

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