| Action of intraoperative radio-frequency for the prolongation of the survival period in patient with multiple large hepatic cancer |
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| Sunday, 28 September 2008 04:05 | |||
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Authors：CHENG Xiang-dong,DU Yi-an,HUANG Ling 【Abstract】 Objective To explore the optimum program for the treatment of patient with multiple large hepatic cancer and analyze mechanism of the action of intraoperative radio-frequency.Methods Forty five admitted patients with multiple large hepatic cancer from January 2003 to January 2007 were classified into:simple hepatic artery embolization chemotherapy group（TACE group,n=20）;local resection of multiple lesion +TACE（LR+TACE group,n=13）;intraoperative radio-frequency ablation+TACE（IRFA+TACE group,n=12）.A comparison of the complete remission rate and survival rate between the 3 groups was made.We analyzed the survival rate with Kaplan-Meier method,and checked the validity with long-rank method.Results No patient died in the treatment.The complete remission rate in IRFA+TACE,LR+TACE and TACE groups were 41.70%,46.20% and 25.50% respectively,being highest in LR+TACE group but had no statistical significance（P=0.405）.Recent survival rate（0.5,1-year survival rate）had no notable difference,but the remote survival rate in IRFA+TACE group was significantly higher than that of the other 2 groups,the 1.5 years and 2.0 years survival rate in the 3 groups being 75.00%,69.20%,30.00% and 50.00%,23.10%,10.00% respectively（P＜0.05）.The mean survival period in the 3 groups being 26.56 months,21.04 months,16.41 months respectively and had significant difference（P<0.001）.Kaplan-Meier survival curve suggested the overall survival rate in IRFA group was significantly higher than that of the other 2 groups（P＜0.05）.As compared with the elevation of the overall survival rate,there was no significant difference of tumorless survival rate between IRFA+TACE group and LR+TACE group（P=0.645）,and the tumorless survival rate in TACE group was still significantly lower than that in the other 2 groups（P<0.022）.The prolongation of the survival period in patients with multiple macronodular hepatic after IRFA+TACE treatment was mainly embodied in the prolongation of survival period in tumor carrying patient,and local resection was unable to prolong the survival period in tumor carrying patient（P=0.028）.Conclusion Combination treatment with IRFA and TACE is a safe optimum therapeutic program in patients with multiple macronodular hepatic cancer for the prolongation of survival period.The mechanism may be the enhancement of cellular immunity,maintaining a dynamic balance between the host and the tumor which takes part in the action on the prolongation of the overall survival period. 【Keywords】 multiple hepatic cancer；large hepatic cancer；radio-frequency ablation；cellular immunity Add this page to your favorite Social Bookmarking websites         
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